How to set up the Filter?
Select the Email List that you wish to filter. Under List Maintanence select the Email Filter option: Screenshot
Enter in a name for the Filter: Screenshot
Enter in the values for the Custom Variables based on which you wish to filter the list: Screenshot
How to send only to the filtered email addresses?
Under Send Email Invitation select the list and click on the Send Email Invitation button: Screenshot
From the Filter drop menu select the saved filter and send: Screenshot
See example: